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amd
GPU
256GB VRAM
workstation

AMD Instinct MI325X

256GB HBM3e — direct competitor to NVIDIA H200 with more memory.

Released 2024

Overview

256GB HBM3e — direct competitor to NVIDIA H200 with more memory.

Specs

VRAM256 GB
Power draw1000 W
Released2024
MSRP$20000
Backends
ROCm

Models that fit

Open-weight models small enough to run on AMD Instinct MI325X with usable context.

Llama 3.1 8B Instruct
8B · llama
Llama 4 Scout
109B · llama
Qwen 3 30B-A3B
30B · qwen
Qwen 2.5 Coder 32B Instruct
32B · qwen
Llama 3.3 70B Instruct
70B · llama
Qwen 3 32B
32B · qwen
Gemma 4 31B Dense
31B · gemma
Qwen 3 8B
8B · qwen

Frequently asked

What models can AMD Instinct MI325X run?

With 256GB VRAM, the AMD Instinct MI325X runs 70B models in 4-bit quantization, plus everything smaller. See the model list below for tested combinations.

Does AMD Instinct MI325X support CUDA?

No — AMD Instinct MI325X is an AMD card. Use ROCm (Linux) or the Vulkan backend in llama.cpp instead. CUDA-only tools won't work.

Reviewed by RunLocalAI Editorial. See our editorial policy for how we research and verify hardware specifications.